精选医学文献治疗大龄女和卵巢功能早

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文献：

NovelmethodsoftreatingovarianinfertilityinolderandPOFwomen,testicularinfertility,andotherhumanfunctionaldiseases

AntoninBukovsky1

ReproductiveBiologyandEndocrinology:10

DOI:10./s---8

?Bukovsky;licenseeBioMedCentral.2

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Abstract

Invitromaturation(IVM)andemdemandsofolderwomentoconceive.Althoughovarianstemcells(OSCs)ofolderwomenarecapableofproducinginvitrofreshoocyte-likecells(OLCs),suchcellscannotrespondtoIVMandIVFduetothelackofgranulosacellsrequiredfortheirmaturation.Follicularrenewalisalsodependentonsupportofcirculatingbloodmononuclearcells.Theyinduceintermediarystagesofmeiosis(metaphaseIchromosomalduplicationandcrossover,anaphase,telophase,andcytokinesis)innewlyemergingovariangermcells,asforthefirsttimedemonstratedhere,induceformationofgranulosacells,andstimulatefolliculargrowthanddevelopment.ApretreatmentofOSCculturewithmononuclearcellscollectedfrombloodofayounghealthyfertilewomanmaycausedifferentiationofbipotentialOSCsintobothdevelopinggermandgranulosacells.Asmallbloodvolumereplacementmayenabletreatmentofovarianinfertilityinvivo.Thetransferredmononuclearcellsmaytemporarilyrejuvenatevirtuallyalltissues,includingimprovementofthefunctionofendocrinetissues.FormationofnewfolliclesandtheirdevelopmentmaybesufficientforIVMandIVF.Thenovelproposedinvitroapproachesmaybeusedasasecondpossibility.Infertilityofhumanmalesaffectsalmostahalfoftheinfertilitycasesworldwide.Smallbloodvolumereplacementfromyounghealthyfertilemenmayalsobeeasyapproachfortheimprovementofspermqualityinolderorotheraffectedmen.Inaddition,bodyrejuvenationbysmallbloodvolumereplacementfromyounghealthyindividualsofthesamesexcouldrepresentadeclineofinvitromethodologyinfavorofinvivotreatmentforhumanfunctionaldiseases.Hereweproposeforthefirsttimethatbloodmononuclearcellsareessentialforrejuvenationofthosetissues,whereimmunesystem







































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